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Looking for girlfriend > Looking for boyfriend > Why would a man need to take estrogen

Why would a man need to take estrogen

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Our doctors understand that simply giving a man testosterone will not alleviate his symptoms. In fact, if a healthcare practitioner gives a man testosterone without also managing estrogen, he will likely feel worse in the short term, and his prostate cancer risk will be increased in the long term. Because restoring the balance between testosterone and estrogen is vital to overcoming your andropause symptoms, our doctors pay particular attention to estrogen, and manage it as necessary. You can bet on that.

SEE VIDEO BY TOPIC: Taking Estrogen After Menopause: What You and Your Heart Need to Know

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Menopause for men: estrogen affects middle-aged males

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Androgens are essential for male physical activity and normal erectile function. Moreover, estrogens also influence erectile function, and high estrogen levels are a risk factor for erectile dysfunction ED. In this review, we summarize relevant research examining the effects of the sex hormone milieu on erectile function. Testosterone affects several organs, particularly erectile tissue.

The mechanisms through which testosterone deficiency affects erectile function and the results of testosterone replacement therapy have been extensively studied. Estrogen, the female sexual hormone, also affects erectile function, as demonstrated in both clinical and basic studies. Interestingly, estradiol-testosterone imbalance is considered a risk factor for ED.

Furthermore, endocrine-disrupting chemicals have estrogen-like effects and cause ED. Phosphodiesterase-5 PDE-5 inhibitors, first-line drugs for the treatment of ED, increase the levels of testosterone and estradiol in patients with low testosterone levels. Therefore, estrogen levels should be carefully monitored in patients receiving PDE-5 inhibitors. Future studies are needed to confirm these findings using molecular tools in order to provide insights into the treatment and mechanisms of endocrine-related ED.

Serum estrogen levels are correlated with symptoms of aging in men, and estrogen may therefore play an important role in aging [ 1 , 2 ]. Several previous studies have suggested that estrogen levels may also affect erectile function [ 3 , 4 , 5 , 6 ]. Indeed, older and obese men have been found to have not only low androgen levels but also high estrogen levels.

Since testosterone is metabolized to estradiol by aromatase, the particularly high aromatase levels in visceral adipose tissue may explain the elevated estradiol levels among obese men [ 7 ]. Visceral adipose tissue often accumulates among men with increasing age. Interestingly, high estrogen levels have been observed in older patients who present with a lack of sexual interest and erectile dysfunction ED ; therefore, these symptoms in the elderly are thought to involve a pathophysiological estrogen-testosterone imbalance [ 6 , 8 , 9 , 10 ].

Accordingly, in this review, we discuss the effects of sex hormone imbalances on male erectile function. There are many reports on erectile function and sexual hormones. Erectile function is controlled by complex mechanisms [ 11 ], including the vascular and nervous systems [ 12 , 13 , 14 , 15 , 16 ].

One of the most important materials is a nitric oxide NO. After NO is releasing in the penis, corporal smooth muscle relaxes. However, when NO production is decreased, the erectile function weakened, resulting in ED. The relaxant system is also important for the erectile function.

The relaxant system is controlled by both the endothelial and the nervous systems. When the upper stream of smooth muscle relaxant system is weakened, ED is caused; therefore, many studies have focused on smooth muscle relaxation.

In contrast, corporal smooth muscle contraction is controlled by constrictors, such as noradrenaline in the flaccid state. However, if the contraction be upregulated in some situations, ED would be caused. Interestingly, some studies have indicated that smooth muscle relaxation and contraction balance is disturbed by abnormal activation of contractile signaling pathway such as the adrenergic regulation.

In some syndromes causing ED, such as diabetes mellitus or metabolic syndrome, the contraction is enhanced [ 17 , 18 , 19 ]. The enhancement is known to occur in aged individuals.

Interestingly, the contractility of smooth muscle in the corpus cavernosum is regulated by sexual hormones and may play a significant role in erectile function. Testosterone deficiency and ED have been studied extensively [ 22 , 23 , 24 , 25 ].

Testosterone deficiency causes ED using castrated animal models [ 26 ]. In some studies, testosterone administration to the castrated animals improved NOS expression in the penis and restored the erectile function [ 27 ]. Testosterone also alters phosphodiesterase type 5 PDE-5 expression in the penis. These results indicate that testosterone is important for regulating PDE-5 expression. Testosterone also affects the smooth muscle of the corpus cavernosum. Moreover, testosterone modulates the adrenergic response of the corpus cavernosum vascular smooth muscle [ 33 ].

These results indicate that when testosterone levels decrease, smooth muscle contractility also decreases. Their results indicated that testosterone deficiency increased smooth muscle contractility, leading to the decreasing erectile function and hypertension. Thus, although testosterone deficiency may increase contraction, additional research is required to more fully elucidate its impact on smooth muscle contraction.

Interestingly, testosterone also directly affects smooth muscle relaxation. These findings indicate that testosterone may regulate erectile function locally by acting on corpus cavernosum smooth muscle. These results indicate that testosterone may affect both genomic and nongenomic mechanisms of erectile function.

Testosterone also affects the structure of the penis. For example, castrated rats exhibit smooth muscle loss and fibrosis [ 37 ], and testosterone deficiency increases the volume of collagen in the internal pudendal arteries [ 38 ].

These effects of testosterone indicate that testosterone deficiency causes programmed trabecular smooth muscle cell death apoptosis [ 29 ]. Although their report had several limitations, they discussed the important role of testosterone in regulating the structural integrity of the corpus cavernosum and erectile function. This resulted from testosterone regulating the counterregulation of autophagy and apoptosis by modulating the interactions between BECN1 and Bcl-2 key dual regulators of autophagy and apoptosis [ 41 , 42 ].

Estrogen, the female sex hormone, also affects erectile function. They show that testosterone has a negative association with the degree of atherosclerotic disease in the lower extremities [ 43 ].

On the other hand, estrogen also has association with ABI negatively in the males, leading to higher estradiol levels associated with increased atherosclerosis. Moreover, both low testosterone levels and elevated estradiol levels affect erectile function and are associated with increased ED severity when present individually or concomitantly [ 44 ].

Low testosterone levels were thought to be the main effector; however, the presence of concomitantly elevated estradiol levels increased the severity of ED in patients with low testosterone levels. These reports indicated that female sex hormones also affect male health.

Srilatha and Adaikan demonstrated that estradiol-testosterone imbalance is a risk factor for ED [ 8 , 45 , 46 ]. They showed that higher levels of estradiol were present in older patients experiencing with lack of sexual interest and ED, after adjustment for age [ 8 ]. Additionally, they concluded that the estradiol-testosterone hormonal balance may be a determinant of successful management outcomes for ED.

These reports specifically demonstrated the relationship between high estrogen milieu and male erectile function.

Serum estrogen levels are controlled by aromatase but can be altered under some conditions. Moreover, they found that total estradiol levels may be increased based on sex hormone-binding globulin SHBG levels. Drugs such as phenytoin are known to cause elevations in serum estradiol and SHBG [ 50 ].

All these side effects have been reported in association with antiretroviral therapy as well. SHBG, similar to other globulins, is upregulated in patients with acquired immunodeficiency syndrome and human immunodeficiency virus infection [ 57 , 58 ]. They showed that overhydration in hemodialysis patients was associated with a higher prevalence of sexual dysfunction and depression, lower serum levels of total testosterone and dehydroepiandrosterone, and higher levels of serum estradiol.

They also reported that elderly men with low serum testosterone and estradiol have increased risk of mortality and that patients with low testosterone and estradiol levels have the highest risk of mortality [ 61 ]. Serum estrogen levels can be altered by some drugs and sex hormones. Therefore, ED induced by high estrogen may be related to mortality.

Interestingly, estrogen administration decreases erectile function in animal models [ 62 , 63 ]. Researchers administered estradiol orally to rats, resulting in high estradiol levels and low testosterone levels.

Moreover, the intracavernous pressure ICP response to nerve stimulation was also impaired in all treated groups, and trichrome staining demonstrated the presence of cavernosal connective tissue hyperplasia in long-term study groups [ 62 ]. Oral administration of estradiol to rabbits resulted in high estradiol levels and low testosterone levels, similar to the effects in rats.

Additionally, acetylcholine induced endothelium-mediated relaxation in normal animals, but this effect was significantly attenuated in treated groups, and NO-mediated nonadrenergic, noncholinergic neurotransmission was decreased in the treatment groups [ 63 ].

In our previous studies, subcutaneous administration s. Moreover, we administered testosterone to rats with high estrogen-induced testosterone deficiency; however, erectile function did not improve. We also investigated the influence of estradiol-testosterone imbalance on erectile function in rats Figures 1 — 6 ; Table 1.

Table 1 shows the sex hormone concentrations in rats. Goserelin injection significantly decreased serum bioavailable testosterone control: 1. Testosterone injection significantly increased serum bioavailable testosterone control: 1. Estradiol injection significantly increased serum estrogen control: Experimental design. Measurement of intracavernous pressure ICP. The contraction curves induced by noradrenaline NA in rat corpus cavernosum strips.

Emax values are reported in the text. The relaxation curve induced by sodium nitroprusside SNP in rat corpus cavernosum strips. IC50 values are reported in the text. A Representative specimens of corpus cavernosum of each group rats. B Histological evaluation of the tissues. The area ratios of the collagen fibers, smooth muscle SM , and others were calculated using computerized image analysis.

Figure 2 shows the erectile response to electrical field stimulation of the cavernous nerve in the different experimental groups. These data suggested that erectile responses were decreased in rats with a sex hormone imbalance.

Figure 3 shows the contractile response of rat corpora cavernosa strips to increasing concentrations of noradrenaline NA. Increasing concentrations of NA were found to contract rat corpora cavernosa strips in all groups. Figures 4 and 5 show the relaxant response of NA-precontracted rat corpora cavernosa strips to increasing concentrations of sodium nitroprusside SNP and Y The area ratio of the cavernous smooth muscle was analyzed control: Similarly, the area ratio of the collagen fiber was analyzed control: Several reports have suggested an association between ERs and ED.

These reports indicate that the ER exists in the corpus cavernosum and has various functions.

Male Estrogen Therapy

In men, oestrogen has a beneficial effect on bone metabolism, preventing the appearance of osteoporosis and contributing to the ageing of the joints during pubertal development. That is to say, oestrogen contributes, in part at least, to delaying the appearance of atheromatous plaque that may later cause cardiovascular events. In addition, oestrogen enhances insulin function reducing glycemia , regulates appetite, energy expenditure, and as a consequence of this can be deemed detrimental to an individuals body weight. Oestrogen is responsible for the difference between women and men in terms of cardiovascular health.

Feminizing hormone therapy is used to induce physical changes in your body caused by female hormones during puberty secondary sex characteristics to promote the matching of your gender identity and your body gender congruence. If feminizing hormone therapy is started before the changes of male puberty begin, male secondary sex characteristics, such as increased body hair and changes in voice pitch, can be avoided. Feminizing hormone therapy is also referred to as cross-sex hormone therapy.

As the novel coronavirus swept through communities around the world, preying disproportionately on the poor and the vulnerable, one disadvantaged group has demonstrated a remarkable resistance. Women, whether from China, Italy or the U. Which has made doctors wonder: Could hormones produced in greater quantities by women be at work? The two clinical trials will each dose men with the sex hormones for limited durations. Last week, doctors on Long Island in New York started treating Covid patients with estrogen in an effort to increase their immune systems, and next week, physicians in Los Angeles will start treating male patients with another hormone that is predominantly found in women, progesterone, which has anti-inflammatory properties and can potentially prevent harmful overreactions of the immune system.

The role of estradiol in male reproductive function

While its importance is normally attributed to women, estrogen in men plays an important role. As teenagers, men have high levels of testosterone and low levels of estrogen. As they age, testosterone levels in men decrease while their estrogen levels increase. Not surprisingly, high levels of estrogen in men usually correspond to low levels of testosterone. High estrogen levels in men contribute to prostate cancer and heart disease as well as gynecomastia enlarged breasts. As the testosterone is transformed into estrogen the low levels of testosterone can cause many unpleasant symptoms including loss of muscle mass , fatigue , low libido , erectile dysfunction. Furthermore, excessive estrogen in men raises body fat and can contribute to diabetes and high lipids. Testosterone will begin to convert to estrogen in men as they age due to the aromatase reaction. Aromatase is found most prevalently in fat cells, so the more body fat a man has, especially in the midsection, the more aromatase and hence the more estrogen.

Learn More About Estrogen Levels In Men

Androgens are essential for male physical activity and normal erectile function. Moreover, estrogens also influence erectile function, and high estrogen levels are a risk factor for erectile dysfunction ED. In this review, we summarize relevant research examining the effects of the sex hormone milieu on erectile function. Testosterone affects several organs, particularly erectile tissue. The mechanisms through which testosterone deficiency affects erectile function and the results of testosterone replacement therapy have been extensively studied.

Men are often unaware that estrogen estradiol plays a critical role in their day-to-day health.

Researchers have discovered that, just as women go through menopause due to a dramatic decrease in estrogen production, middle-aged men undergo estrogen-related changes in body composition and sexual function. The researchers say that traditionally, when a diagnosis of male hypogonadism has been made — a drop in reproductive hormone levels that are high enough to cause physical symptoms — it has only been based on blood testosterone levels. However, they say there has been little understanding of the levels of testosterone needed to support certain functions.

Why Is Estrogen Important for Men?

The effects of different doses of transdermal estradiol TE on bone mineral density BMD in a man with aromatase deficiency were evaluated. X-rays of hands, legs, and pelvis were performed, and BMD of the lumbar spine, hormonal parameters LH, FSH, testosterone, and estradiol , and markers of bone turnover were determined during each phase. BMD in phase 1 was 0.

SEE VIDEO BY TOPIC: Estrogen - Reproductive system physiology - NCLEX-RN - Khan Academy

Why is estrogen important for men? Men are more concerned about their testosterone level, especially as men age beyond 40 and testosterone starts to decline naturally. Men are also concerned about having too much testosterone when they have prostate cancer and may need to have hormone therapy. But a proper balance among estrogen and testosterone is key to good prostate health and good heart health. Here are the answers to W hy is estrogen important for men? Too little estrogen can predispose men to osteoporosis and lead to bone fractures.

The importance of oestrogen for men

Traditionally, testosterone and estrogen have been considered to be male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a critical role in male sexual function. Estradiol in men is essential for modulating libido, erectile function, and spermatogenesis. Estrogen receptors, as well as aromatase, the enzyme that converts testosterone to estrogen, are abundant in brain, penis, and testis, organs important for sexual function. In the brain, estradiol synthesis is increased in areas related to sexual arousal.

In contrast, the precise role of estrogen in human male physiology remains unknown. the male as well as estrogens do in the female continues to be the prevailing The inter- and intraassay coefficients of variation for estradiol were 5% and  by V Rochira - ‎ - ‎Cited by - ‎Related articles.

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Estrogen for Male Function: Effect of Changes in the Sex Hormone Milieu on Erectile Function

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Comments: 2
  1. Mikazahn

    Instead of criticising write the variants is better.

  2. Kelkis

    Here those on!

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